Cognitive decline and dementia independent of Alzheimer's pathology 

 
   Lead Investigator:    Juan Troncoso
   Institution      :    Johns Hopkins
   E-Mail           :    troncoso@jhmi.edu
   Proposal ID      :    484



   Proposal Description:
   The specific aims of this analysis are:   1) In individuals with no AD pathologic changes (Neuritic plaque score 0 (CERAD)) compare the neuropathology of subjects with and without dementia  2) In individuals with no AD pathologic changes, compare demographic, family history, CVD profile, UPDRS scores, and daily function (FAQ) in subjects with and without dementia  3) IN individuals with non-AD dementia, compare demographic, family history, HIS and CVD data, UPDRS scores, behavioral assessments, functional assessment, MMSE total score and neuropsychological test scores across disorders.   4) In individuals with non-AD dementia test the hypothesis that the incidence of hippocampal sclerosis increases with age